New insights on resveratrol supported by magnesium dihydroxide (Revifast®)
Main Article Content
Keywords
dissolution rate, magnesium dihydroxide, microparticles, resveratrol, spectroscopy
Abstract
Based on low solubility in water and high membrane permeability, resveratrol is collocated in the second class of the Biopharmaceutical Classification System, with limited absorption derived from a low dissolution rate. Solid microdispersion of resveratrol supported by magnesium dihydroxide (Resv@MDH, trademark Revifast®) represents a physical mixture of resveratrol (30% w/w) and magnesium dihydroxide (70% w/w) obtained by traditional techniques, such as mixing and micronization under appropriate conditions. Establishing the wide use of Revifast® in food supplements, in the present work we deepen its physicochemical characterization by using diffractometric and infrared analysis. No novel species are found in the Resv@MDH mixture except magnesium dihydroxide and resveratrol extracted from Polygonum cuspidatum. The results herein reported strengthened the safety of Revifast® ingredients for resveratrol-based food supplements.
References
Amiot M.J., Romier B., Dao T.-M.A., Fanciullino R., Ciccolini J., Burcelin R., et al. 2013. Optimization of trans-resveratrol bio-availability for human therapy. Biochimie 95(6): 1233–1238. 10.1016/j.biochi.2013.01.008
Amri A., Chaumeil J.C., Sfar S. and Charrueau C. 2012. Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release (JCR). 158(2): 182–193. 10.1016/j.jconrel.2011.09.083
Baur J.A. and Sinclair D.A. 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 5(6): 493–506. 10.1038/nrd2060
Curry A.M., White D.S., Donu D. and Cen Y. 2021. Human sirtuin regulators: the “success” stories. Front Physiol. 12: 752117. 10.3389/fphys.2021.752117
Das S., Lin H.-S., Ho P.C. and Ng K.-Y. 2008. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res. 25(11): 2593–2600. 10.1007/s11095-008-9677-1
Domi E., Hoxha M., Kolovani E., Tricarico D. and Zappacosta B. 2022. The importance of nutraceuticals in COVID-19: what’s the role of resveratrol? Molecules (Basel, Switzerland). 27(8): 2376. 10.3390/molecules27082376
Gerli S., Morte C.D., Ceccobelli M., Mariani M., Favilli A., Leonardi L., et al. 2022. Biological and clinical effects of a resveratrol-based multivitamin supplement on intracytoplasmic sperm injection cycles: a single-center, randomized controlled trial. J Maternal Fetal Neonatal Med. 35(25): 7640–7648. 10.1080/14767058.2021.1958313
Güder A., Korkmaz H., Gökce H., Alpaslan Y.B. and Alpaslan G. 2014. Isolation, characterization, spectroscopic properties and quantum chemical computations of an important phytoalexin resveratrol as antioxidant component from Vitis Labrusca L. and their chemical compositions. Spectrochim Acta A Mol Biomol Spectrosc. 133(Dec.): 378–395. 10.1016/j.saa.2014.05.056
Hurst S., Loi C.-M., Brodfuehrer J. and El-Kattan A. 2007. Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bio-availability of rats and humans. Expert Opin Drug Metab Toxicol. 3(4): 469–489. 10.1517/17425225.3.4.469
Iannitti R.G., Floridi A., Lazzarini A., Tantucci A., Russo R., Ragonese F., et al. 2020. Resveratrol supported on magnesium hydroxide (Resv@MDH) represents an oral formulation of resveratrol with better gastric absorption and bioavailability respect to pure resveratrol. Front Nutr. 7: 570047. 10.3389/fnut.2020.570047
Illiano E., Trama F., Zucchi A., Iannitti R.G., Fioretti B. and Costantini E. 2020. Resveratrol-based multivitamin supplement increases sperm concentration and motility in idiopathic male infertility: a pilot clinical study. J Clin Med. 9(12): 4017. 10.3390/jcm9124017
Islam F., Nafady M.H., Islam Md. R., Saha S., Rashid S., Akter A., et al. 2022. Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside. Mol Neurobiol. 59(7): 4384–4404. 10.1007/s12035-022-02859-7
Maier-Salamon A., Hagenauer B., Wirth M., Gabor F., Szekeres T. and Jäger W. 2006. Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm Res. 23(9): 2107–2115. 10.1007/s11095-006-9060-z
Malvasi A., Kosmas I., Mynbaev O.A., Sparic R., Gustapane S., Guido M., et al. 2017. Can trans resveratrol plus D-chiro-inositol and myo-inositol improve maternal metabolic profile in over-weight pregnant patients? La Clin Terapeut. 168(4): e240–e247. 10.7417/T.2017.2013
Malvasi A., Tinelli A., Baldini D., Iannitti R.G. and Fioretti B. 2018. Nutraceutical prospective: the synergetic mechanism of action of inositols and resveratrol on metabolic syndrome. EuroBiotech J. 2(1): 35–38. 10.2478/ebtj-2018-0006
Paciotti S., Codini M., Tasegian A., Ceccarini M.R., Cataldi S., Arcuri C., et al. 2017. Lysosomal alpha-mannosidase and alpha-mannosidosis. Front Biosci. 22(1): 157–167. 10.2741/4478
Panico A., Lupoli G.A., Lupoli R., Romano F., Barba L. and Lupoli G. 2017. Resveratrol improves the lipid profile promoted by red yeast rice (Monacolin K.) in patients with moderate dyslipidemia: an open-label, randomized, parallel-group controlled clinical trial. EuroBiotech J. 1(1): 72–75. 10.24190/ISSN2564-615X/2017/01.11
Porto Isabel C.C.M., Nascimento T.G., Oliveira J.M.S., Freitas P.H., Haimeur A. and França R. 2018. Use of polyphenols as a strategy to prevent bond degradation in the dentin-resin interface. Eur J Oral Sci. 126(2): 146–158. 10.1111/eos.12403
Ragonese F., Monarca L., Luca A.D., Mancinelli L., Mariani M., Corbucci C., et al. 2021. Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis. Fertil Steril. 115(4): 1063–1073. 10.1016/j.fertnstert.2020.08.016
Rintz E., Podlacha M., Cyske Z., Pierzynowska K., Węgrzyn G. and Gaffke L. 2023. Activities of (poly)phenolic antioxidants and other natural autophagy modulators in the treatment of san-filippo disease: remarkable efficacy of resveratrol in cellular and animal models. Neurotherapeutics. 20(1): 254–271. 10.1007/s13311-022-01323-7
Spogli R., Bastianini M., Ragonese F., Iannitti R.G., Monarca L., Bastioli F., et al. 2018. Solid dispersion of resveratrol supported on magnesium dihydroxide (Resv@MDH) microparticles improves oral bioavailability. Nutrients. 10(12): 1925. 10.3390/nu10121925
Su M., Zhao W., Xu S. and Weng J. 2022. Resveratrol in treating diabetes and its cardiovascular complications: a review of its mechanisms of action. Antioxidants (Basel, Switzerland). 11(6): 1085. 10.3390/antiox11061085
Wu S.-X., Xiong R.-G., Huang S.-Y., Zhou D.-D., Saimaiti A., Zhao C.-N., et al. 2022. Effects and mechanisms of resveratrol for prevention and management of cancers: an updated review. Crit Rev Food Sci Nutr. 63(33): 12422–12440. 10.1080/10408398.2022.2101428
Amri A., Chaumeil J.C., Sfar S. and Charrueau C. 2012. Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release (JCR). 158(2): 182–193. 10.1016/j.jconrel.2011.09.083
Baur J.A. and Sinclair D.A. 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 5(6): 493–506. 10.1038/nrd2060
Curry A.M., White D.S., Donu D. and Cen Y. 2021. Human sirtuin regulators: the “success” stories. Front Physiol. 12: 752117. 10.3389/fphys.2021.752117
Das S., Lin H.-S., Ho P.C. and Ng K.-Y. 2008. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res. 25(11): 2593–2600. 10.1007/s11095-008-9677-1
Domi E., Hoxha M., Kolovani E., Tricarico D. and Zappacosta B. 2022. The importance of nutraceuticals in COVID-19: what’s the role of resveratrol? Molecules (Basel, Switzerland). 27(8): 2376. 10.3390/molecules27082376
Gerli S., Morte C.D., Ceccobelli M., Mariani M., Favilli A., Leonardi L., et al. 2022. Biological and clinical effects of a resveratrol-based multivitamin supplement on intracytoplasmic sperm injection cycles: a single-center, randomized controlled trial. J Maternal Fetal Neonatal Med. 35(25): 7640–7648. 10.1080/14767058.2021.1958313
Güder A., Korkmaz H., Gökce H., Alpaslan Y.B. and Alpaslan G. 2014. Isolation, characterization, spectroscopic properties and quantum chemical computations of an important phytoalexin resveratrol as antioxidant component from Vitis Labrusca L. and their chemical compositions. Spectrochim Acta A Mol Biomol Spectrosc. 133(Dec.): 378–395. 10.1016/j.saa.2014.05.056
Hurst S., Loi C.-M., Brodfuehrer J. and El-Kattan A. 2007. Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bio-availability of rats and humans. Expert Opin Drug Metab Toxicol. 3(4): 469–489. 10.1517/17425225.3.4.469
Iannitti R.G., Floridi A., Lazzarini A., Tantucci A., Russo R., Ragonese F., et al. 2020. Resveratrol supported on magnesium hydroxide (Resv@MDH) represents an oral formulation of resveratrol with better gastric absorption and bioavailability respect to pure resveratrol. Front Nutr. 7: 570047. 10.3389/fnut.2020.570047
Illiano E., Trama F., Zucchi A., Iannitti R.G., Fioretti B. and Costantini E. 2020. Resveratrol-based multivitamin supplement increases sperm concentration and motility in idiopathic male infertility: a pilot clinical study. J Clin Med. 9(12): 4017. 10.3390/jcm9124017
Islam F., Nafady M.H., Islam Md. R., Saha S., Rashid S., Akter A., et al. 2022. Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside. Mol Neurobiol. 59(7): 4384–4404. 10.1007/s12035-022-02859-7
Maier-Salamon A., Hagenauer B., Wirth M., Gabor F., Szekeres T. and Jäger W. 2006. Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm Res. 23(9): 2107–2115. 10.1007/s11095-006-9060-z
Malvasi A., Kosmas I., Mynbaev O.A., Sparic R., Gustapane S., Guido M., et al. 2017. Can trans resveratrol plus D-chiro-inositol and myo-inositol improve maternal metabolic profile in over-weight pregnant patients? La Clin Terapeut. 168(4): e240–e247. 10.7417/T.2017.2013
Malvasi A., Tinelli A., Baldini D., Iannitti R.G. and Fioretti B. 2018. Nutraceutical prospective: the synergetic mechanism of action of inositols and resveratrol on metabolic syndrome. EuroBiotech J. 2(1): 35–38. 10.2478/ebtj-2018-0006
Paciotti S., Codini M., Tasegian A., Ceccarini M.R., Cataldi S., Arcuri C., et al. 2017. Lysosomal alpha-mannosidase and alpha-mannosidosis. Front Biosci. 22(1): 157–167. 10.2741/4478
Panico A., Lupoli G.A., Lupoli R., Romano F., Barba L. and Lupoli G. 2017. Resveratrol improves the lipid profile promoted by red yeast rice (Monacolin K.) in patients with moderate dyslipidemia: an open-label, randomized, parallel-group controlled clinical trial. EuroBiotech J. 1(1): 72–75. 10.24190/ISSN2564-615X/2017/01.11
Porto Isabel C.C.M., Nascimento T.G., Oliveira J.M.S., Freitas P.H., Haimeur A. and França R. 2018. Use of polyphenols as a strategy to prevent bond degradation in the dentin-resin interface. Eur J Oral Sci. 126(2): 146–158. 10.1111/eos.12403
Ragonese F., Monarca L., Luca A.D., Mancinelli L., Mariani M., Corbucci C., et al. 2021. Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis. Fertil Steril. 115(4): 1063–1073. 10.1016/j.fertnstert.2020.08.016
Rintz E., Podlacha M., Cyske Z., Pierzynowska K., Węgrzyn G. and Gaffke L. 2023. Activities of (poly)phenolic antioxidants and other natural autophagy modulators in the treatment of san-filippo disease: remarkable efficacy of resveratrol in cellular and animal models. Neurotherapeutics. 20(1): 254–271. 10.1007/s13311-022-01323-7
Spogli R., Bastianini M., Ragonese F., Iannitti R.G., Monarca L., Bastioli F., et al. 2018. Solid dispersion of resveratrol supported on magnesium dihydroxide (Resv@MDH) microparticles improves oral bioavailability. Nutrients. 10(12): 1925. 10.3390/nu10121925
Su M., Zhao W., Xu S. and Weng J. 2022. Resveratrol in treating diabetes and its cardiovascular complications: a review of its mechanisms of action. Antioxidants (Basel, Switzerland). 11(6): 1085. 10.3390/antiox11061085
Wu S.-X., Xiong R.-G., Huang S.-Y., Zhou D.-D., Saimaiti A., Zhao C.-N., et al. 2022. Effects and mechanisms of resveratrol for prevention and management of cancers: an updated review. Crit Rev Food Sci Nutr. 63(33): 12422–12440. 10.1080/10408398.2022.2101428
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Published
Feb 24, 2024
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Spogli, R., Biagini, A., Presciutti, F., Petracci, A., Ragonese, F., Giulietta Iannitti, R., Ceccarelli, G., Brecchia, G., Menchetti, L., Codini, M., Rachele Ceccarini, M., Sabbatini, P., & Fioretti, B. (2024). New insights on resveratrol supported by magnesium dihydroxide (Revifast®). Italian Journal of Food Science, 36(1), 175-179. https://doi.org/10.15586/ijfs.v36i1.2481
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How to Cite
Spogli, R., Biagini, A., Presciutti, F., Petracci, A., Ragonese, F., Giulietta Iannitti, R., Ceccarelli, G., Brecchia, G., Menchetti, L., Codini, M., Rachele Ceccarini, M., Sabbatini, P., & Fioretti, B. (2024). New insights on resveratrol supported by magnesium dihydroxide (Revifast®). Italian Journal of Food Science, 36(1), 175-179. https://doi.org/10.15586/ijfs.v36i1.2481