Chamuangone-enriched rice bran oil ameliorates neurodegeneration in haloperidol-induced Parkinsonian rat model via modulation of neuro-inflammatory mediators and suppression of oxidative stress markers
Main Article Content
Keywords
animal behavior, anti-Parkinson, chamuangone, neuro-inflammation, nutraceutical, phytomedicine, rice bran oil
Abstract
A natural bioactive compound chamuangone extracted from Thai salad Garcinia cowa leaves exhibited robust medicinal properties, targeting central oxidative stress pathways, and having neuroprotective potential. Chamuangone-enriched rice bran oil (CERBO), with 1.97 mg/mL chamuangone, was obtained through green extraction. The study was designed to evaluate the anti-Parkinson’s activity of CERBO in the haloperidol- induced Parkinsonian rat model. Animals were categorized into six groups as control, disease control and treatment groups. Parkinson’s disease (PD)-like symptoms were induced by administration of haloperidol 1 mg/kg, intraperitoneally; CERBO treatment groups received 2.5, 5, and 7.5 mg/kg orally before the administration of haloperidol for 21 days. Neurobehavioral, biochemical, neurochemical, and histopathological studies along with gene expression analysis were performed at the completion of the study. CERBO markedly recover the motor and non-motor PD-like symptoms in treatment groups dose-dependently. The levels of antioxidant enzymes, such as catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase, increased, while malondialdehyde levels decreased dose-dependently in CERBO-treated groups. CERBO dose-dependent elevations were observed in neurotransmitters (dopamine, serotonin, and noradrenaline). PD-associated specific biomarker (α-synuclein) decreased dose-dependently with downregulation in messenger RNA expression of neuro-inflammatory mediators (interleukin α, interleukin 1β, and tumor necrosis factor-α). Histopathological studies revealed recovery in neuronal loss, formation of Lewy’s bodies, and neurofibrillary tangles in the treatment groups. It was concluded from the data that CERBO possessed good anti-Parkinson’s activity and could be a novel, safe, and effective remedy for the treatment of PD.
References
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Lakshmi B., Sudhakar M., and Prakash S. 2015. Protective effect of selenium against aluminum chloride-induced Alzheimer’s disease: behavioral and biochemical alterations in rats. Biol Trace Elem Res. 165: 67–74. 10.1007/s12011-015-0229-3
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Lowry H. 1951. Protein measurement with the folin phenol reagent. J Biol Chem. 193: 265–275.
Madiha S., Tabassum S., Batool Z., Liaquat L., Sadir S., and Shahzad S. 2017. Assessment of gait dynamics in rotenone-induced rat model of Parkinson’s disease by footprint method. Pak J Pharm Sci. 30.
Nguyen A., Nguyen N., Hoang P., Doan G., and Lee H. 2022. Six new polyoxygenated xanthones from Garcinia cowa and their neuro-protective effects on glutamate-mediated hippocampal neuronal HT22 cell death. Chem. Biodivers 19: e202200376. 10.1002/cbdv.202200376
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Nottia D., Masciullo M., Verrigni D., Petrillo S., Modoni A., and Rizzo V. 2017. DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7. Clin Genet. 92: 18–25. 10.1111/cge.12841
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Sae-Lim P., Matsunami P., and Panichayupakaranant P. 2022. Chamuangone from Garcinia cowa leaves reduce fat accumulation in Caenorhabditis elegans. Thaksin Univ Online J. (5), INTER-02 (24).
Sae-Lim P., Seetaha S., Tabtimmai L., Suphakun P., Kiriwan D., and Panichayupakaranant P. 2020. Chamuangone from Garcinia cowa leaves inhibits cell proliferation and migration and induces cell apoptosis in human cervical cancer in vitro. J Pharm Pharmacol. 72: 470–480. 10.1111/jphp.13216
Sae-Lim P., Yuenyongsawad S., and Panichayupakaranant P. 2019. Chamuangone-enriched Garcinia cowa leaf extract with rice bran oil: extraction and cytotoxic activity against cancer cells. Pharmacogn Mag. 15(61): 183–188. 10.4103/pm.pm_472_18
Sakunpak A., Matsunami K., and Otsuka H., Panichayupakaranant P. 2017. Isolation of chamuangone, a cytotoxic compound against Leishmania major and cancer cells from Garcinia cowa leaves and its HPLC quantitative determination method. Cancer Res. 6: 38–45. 10.6000/1929-2279.2017.06.02.3
Sakunpak A., and Panichayupakaranant P. 2012. Antibacterial activity of Thai edible plants against gastrointestinal pathogenic bacteria and isolation of a new broad spectrum antibacterial polyisoprenylated benzophenone, chamuangone. Food Chem. 130: 826–31. 10.1016/j.foodchem.2011.07.088
Saleem U., Akhtar R., Anwar F., Shah MA., Chaudary Z., Ayaz M., et al. 2021. Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers. Metab Brain Dis. 36: 889–900. 10.1007/s11011-021-00683-x
Saleem U., Chauhdary Z., Raza Z., Shah S., Rahman U., and Zaib P. 2020. Anti-Parkinson’s activity of tribulus terrestris via modulation of AChE, α-Synuclein, TNF-α, and IL-1β. ACS Omega. 5: 25216–25227. 10.1021/acsomega.0c03375
Saleem U., Shehzad A., Shah S., Raza Z., Shah A., and Bibi S. 2014. Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism. Metab. Brain Dis. 36: 1231–1251. 10.1007/s11011-021-00707-6
Santambrogio P., Dusi S., Guaraldo M., Rotundo I., Broccoli V., and Garavaglia B. 2015. Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients. Neurobio Dis. 81: 144–153. 10.1016/j.nbd.2015.02.030
Sarma A., Sarmah P., Kashyap D., and Kalita A. 2014. Evaluation of nutraceutical properties and antioxidant activity of Garcinia cowa Roxb. Ex choisy fruits found in Assam (India). World J Pharm Pharmaceut Sci. 3: 853–853.
Selvakumar P., Janakiraman U., Essa M., Thenmozhi J., and Manivasagam T. 2014. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/ probenecid mouse model of Parkinson’s disease. Brain Res. 1585: 23–36. 10.1016/j.brainres.2014.03.010
Sharma N., and Bafna P. 2012. Effect of Cynodon dactylon on rotenone-induced Parkinson’s disease. Orient Pharm Exp Med. 12: 167–175. 10.1007/s13596-012-0075-1
Singh A., Kukreti R., Saso L., and Kukreti S. 2019. Oxidative stress: a key modulator in neurodegenerative diseases. Molecules, 24(8): 1583. 10.3390/molecules24081583
Stern B., d’Alencar M., Uscapi L., Gubitoso D., Roque C., and Helene F. 2018. Goalkeeper game: a new assessment instrument in neurology showed higher predictive power than moca for gait performance in people with Parkinson’s disease. Bio Rxiv. 400457. 10.1101/400457
Tillerson L., and Miller W. 2003. Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of Parkinsonism. J Neurosci Methods. 123: 189–200. 10.1016/S0165-0270(02)00360-6
Tysnes B., and Storstein A. 2017. Epidemiology of Parkinson’s disease. J Neural Transm. 124: 901–905. 10.1080/09603123.2022.2047903
Uddin S., Al Mamun A., Asaduzzaman M., Hosn F., Sufian A., and Takeda S. 2018. Spectrum of disease and prescription pattern for outpatients with neurological disorders: an empirical pilot study in Bangladesh. J Neural Transm. 25: 25–37. 10.1159/000481812
Uwishema O., Onyeaka H., Badri R., Yücel N., Korkusuz K., and Ajagbe O. 2022. The understanding of Parkinson’s disease through genetics and new therapies. Brain Behav. 12: e2577. 10.1002/brb3.2577
Wahyuni S., Shaari S., Stanslas J., Lajis N., and Hamidi D. 2015. Cytotoxic compounds from the leaves of Garcinia cowa Roxb. J Appl Pharm Sci. 5: 6–011. 10.7324/JAPS.2015.50202
Wang S.Y. 2010. Correlation of antioxidants and antioxidant enzymes to oxygen radical scavenging activities in berries. In: Seeram N.P., and Stoner G.D. (Eds.) Berries and Cancer Prevention. Springer New York, NY, pp. 79–97. 10.1007/978-1-4419-7554-6_4.
Wang X., Ke L., Chen M., Liu S., and Yu Duan L. 2022. The side effects of dopamine receptor agonist drugs in Chinese prolactinoma patients: a cross sectional study. BMC Endocr Disord. 22: 97. 10.1186/s12902-022-01009-3
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May 10, 2024
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S. Alotaibi, B., Saleem, U., Ahmad, A., Chaudhary, Z., Farrukh, M., O. Khayat, R., Alsharif, I., A. S. Baokbah, T., Albalawi, A. E., A. Althobaiti, N., Ajmal Shah, M., Anam, K., F. Alanazi, Y., Panichayupakaranant, P., Blundell, R., & Sanches Silva, A. (2024). Chamuangone-enriched rice bran oil ameliorates neurodegeneration in haloperidol-induced Parkinsonian rat model via modulation of neuro-inflammatory mediators and suppression of oxidative stress markers. Italian Journal of Food Science, 36(2), 163-180. https://doi.org/10.15586/ijfs.v36i2.2551
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How to Cite
S. Alotaibi, B., Saleem, U., Ahmad, A., Chaudhary, Z., Farrukh, M., O. Khayat, R., Alsharif, I., A. S. Baokbah, T., Albalawi, A. E., A. Althobaiti, N., Ajmal Shah, M., Anam, K., F. Alanazi, Y., Panichayupakaranant, P., Blundell, R., & Sanches Silva, A. (2024). Chamuangone-enriched rice bran oil ameliorates neurodegeneration in haloperidol-induced Parkinsonian rat model via modulation of neuro-inflammatory mediators and suppression of oxidative stress markers. Italian Journal of Food Science, 36(2), 163-180. https://doi.org/10.15586/ijfs.v36i2.2551