Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments

Main Article Content

A.A. Moazzami
M. Coulomb
A. Gombert

Keywords

metabolomics, NMR, wholegrain, rye, wheat, metabolites, biomarkers

Abstract

This study used NMR-based metabolomics to compare the metabolic profile of different anatomical compartments of cereal grains i.e. bran and endosperm in order to gain further insights
into their possible role in the beneficial health effects of whole grain products (WG). Polar watersoluble metabolites in 64 bran and endosperm, samples from rye and wheat were observed using
600 MHz NMR. Bran samples had higher contents of 12 metabolites than endosperm samples. A comparative approach revealed higher contents of azelaic acid and sebacic acid in bran than in endosperm. In a pilot study, the consumption of WG rye bread (485 g) caused NMR signals in 24h urine corresponding to azelaic acid. The relatively high abundance, anatomical specificity, pattern
of metabolism, urinary excretion in human, antibacterial, and anticancer activities suggest further studying of azelaic acid when exposure to WG or beneficial effects of WG are investigated.
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